Pharmacologic Aspects of Synthetic Angiotonin
نویسندگان
چکیده
منابع مشابه
Pharmacologic aspects of synthetic angiotonin.
Tho. synthetic octapeptide angiotonin evoked systolic and diastolic pressure responses in anesthetized and unanesthetized dogs identical with those due to a natural, largely decapeptide, angiotonin, and responses to both angiotonins were modified in the same manner by a variety of procedures. Infusion of synthetic angiotonin caused hypertension sustained for the durations of the infusions and t...
متن کاملEffect of synthetic angiotonin on the carotid sinus.
Natural decapeptide or synthetic octapeptide angiotonin was ineffective in lowering arterial pressure or decreasing the carotid occlusion response when injected into the carotid sinus adventitia. Injection of synthetic octapeptide angiotonin into the lumen of the carotid sinus after tying its branches decreased the carotid occlusion response but the effect depended on dosage many times the pres...
متن کاملSynthesis and properties of angiotonin.
ANGIOTONIN (hypertensin) was discovered in 1939, but it was not until 1956 that its structure was reported. In 1954 we published an amino acid analysis and a determination of the end amino acids of angiotonin. We know now that the preparation used was about 75 per cent pure, which accounts for the additional amino acids reported; the end amino acids were later shown to be correct. During the pu...
متن کاملAngiotonin-activator, Renin- and Angiotonin-inhibitor, and the Mechanism of Angiotonin Tachyphylaxis in Normal, Hypertensive, and Nephrectomized Animals
1. Angiotonin does not exert its vasoconstrictor effect in the absence of a substance contained in red blood cells and serum which we have called "angiotonin-activator." A fraction has been separated from blood in which angiotonin-activator is concentrated. It contains little or no reninactivator. 2. Repeated intravenous injections of angiotonin into animals causes the pressor response graduall...
متن کاملChemical Aspects of Synthetic Biology
Synthetic biology as a broad and novel field has also a chemical branch: whereas synthetic biology generally has to do with bioengineering of new forms of life (generally bacteria) which do not exist in nature, 5chemical synthetic biology6 is concerned with the synthesis of chemical structures such as proteins, nucleic acids, vesicular forms, and other which do not exist in nature. Three exampl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 1957
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.5.5.552